Invention Grant
- Patent Title: High concentration immunoglobulin composition for pharmaceutical application
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Application No.: US16308356Application Date: 2017-06-12
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Publication No.: US11191833B2Publication Date: 2021-12-07
- Inventor: Karin Ahrer , Waltraud Kaar , Ulrich Roessl
- Applicant: OCTAPHARMA AG
- Applicant Address: CH Lachen
- Assignee: OCTAPHARMA AG
- Current Assignee: OCTAPHARMA AG
- Current Assignee Address: CH Lachen
- Agency: Marshall, Gerstein & Borun LLP
- Priority: EP16174019 20160610
- International Application: PCT/EP2017/064279 WO 20170612
- International Announcement: WO2017/212067 WO 20171214
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K47/18 ; A61K9/00 ; A61K9/08 ; A61K47/22 ; A61K39/00

Abstract:
The present invention relates to a liquid composition comprising polyclonal immunoglobulins, at least one viscosity modulating amino acid, selected from arginine and histidine, and at least one stabilising amino acid, selected from glycine and proline, wherein more than 90% of the polyclonal immunoglobulins are in the form of monomers or dimers and less than 5% in the form of polymers, and wherein the immunoglobulin concentration in the composition is above 160 g/L and the pH is in the range from 5.2 to 5.9. The invention further relates to a liquid composition for use in medical treatment, to amino acids for formulating a highly concentrated polyclonal immunoglobulins as well as a method of formulating.
Public/Granted literature
- US20190125868A1 HIGH CONCENTRATION IMMUNOGLOBULIN COMPOSITION FOR PHARMACEUTICAL APPLICATION Public/Granted day:2019-05-02
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