Invention Grant
- Patent Title: Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
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Application No.: US16297190Application Date: 2019-03-08
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Publication No.: US11192849B2Publication Date: 2021-12-07
- Inventor: Brent R. Stockwell , Rachid Skouta , Scott Dixon
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Bryan Cave Leighton Paisner LLP
- Main IPC: C07C229/56
- IPC: C07C229/56 ; A61K31/245 ; A61K45/06 ; A61K31/196 ; A61K31/505 ; C07C255/58 ; C07C271/24 ; C07C229/60 ; C07D401/12 ; C07D239/26 ; C07D213/38
Abstract:
The present invention provides, inter alia, a compound having the structure of Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
Public/Granted literature
- US20190292135A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS Public/Granted day:2019-09-26
Information query
