![Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt](/docs/US/2021-12-07/US11192895B2/abs.jpg.600x600.jpg)
- Patent Title: Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt
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Application No.: US17318677Application Date: 2021-05-12
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Publication No.: US11192895B2Publication Date: 2021-12-07
- Inventor: Christopher K. Murray , Leonard W. Rozamus , John J. Chaber , Pradeep K. Sharma
- Applicant: ARIAD Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ARIAD Pharmaceuticals, Inc.
- Current Assignee: ARIAD Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Main IPC: C07D487/04
- IPC: C07D487/04
![Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide and its mono hydrochloride salt](/abs-image/US/2021/12/07/US11192895B2/abs.jpg.150x150.jpg)
Abstract:
Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein.
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