Invention Grant
- Patent Title: Scalable process for oncolytic rat parvovirus H-1 production and purification based on isoelectric point-based elimination of empty particles
-
Application No.: US16400851Application Date: 2019-05-01
-
Publication No.: US11193112B2Publication Date: 2021-12-07
- Inventor: Barbara Leuchs , Jean Rommelaere , Veronika Frehtman , Markus Riese
- Applicant: Deutsches Krebsforschungszentrum
- Applicant Address: DE Heidelberg
- Assignee: Deutsches Krebsforschungszentrum
- Current Assignee: Deutsches Krebsforschungszentrum
- Current Assignee Address: DE Heidelberg
- Agency: Perkins Coie LLP
- Agent Viola T. Kung
- Priority: EP16198026 20161109
- Main IPC: C12N7/02
- IPC: C12N7/02 ; C12N7/00
Abstract:
The present invention provides a reproducible, effective and scalable process for the purification of (infectious) parvovirus H-1 particles. The purification process allows the separation of empty particles from particles containing a full genome and is compatible with large-scale H-1PV production for clinical applications.
Public/Granted literature
Information query
