- Patent Title: Recombinant microorganism having enhanced ability to produce heme, coproporphyrin III, and uroporphyrin III, and method for producing heme, coproporphyrin III, and uroporphyrin III using same
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Application No.: US16611929Application Date: 2018-05-18
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Publication No.: US11193152B2Publication Date: 2021-12-07
- Inventor: Sung Ok Han , Young-jin Ko
- Applicant: Korea University Research and Business Foundation
- Applicant Address: KR Seoul
- Assignee: Korea University Research and Business Foundation
- Current Assignee: Korea University Research and Business Foundation
- Current Assignee Address: KR Seoul
- Agency: NSIP Law
- Priority: KR10-2017-0061713 20170518,KR10-2018-0056906 20180518
- International Application: PCT/KR2018/005740 WO 20180518
- International Announcement: WO2018/212626 WO 20181122
- Main IPC: C12N1/21
- IPC: C12N1/21 ; C12N9/02 ; C12N9/90 ; C07K14/34 ; C12P9/00 ; C12P17/18
Abstract:
The present invention relates to a recombinant microorganism having an enhanced ability to produce heme, coproporphyrin III (Copro III), and uroporphyrin III (Uro III), and a method for producing heme, coproporphyrin III, and uroporphyrin III using same. When using a recombinant microorganism incorporating a gene that codes glutamyl-tRNA reductase (HemA), glutamate-1-semialdehyde aminotransferase (HemL), and diphtheria toxin repressor (DtxR), which is a transcription factor capable of inducing the expression of genes related to heme metabolic pathways, porphyrin-based structures can be produced at high yield, and thus the method is economic.
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