An exemplary client virtualization system implemented by a multi-access server receives a service request from an Internet of Things (“IoT”) device that is separate from and communicatively coupled to the multi-access server. In response to the service request, the client virtualization system instantiates a virtualized device management client configured to serve the IoT device and that is hosted on the multi-access server. The client virtualization system receives a device management message that is for the IoT device and that is from a centralized device management server. The client virtualization system then delivers the device management message to the IoT device. Corresponding methods and systems are also disclosed.