A method for depopulating data from cache includes receiving a command to depopulate the cache of selected data. The command has an application identifier as a parameter. The application identifier is associated with an application that previously accessed the data. The method searches the cache for data elements that are marked with the application identifier and removes the data elements from the cache. In certain embodiments, the data elements are marked with a first application identifier associated with an application that staged the data elements into the cache, and a second application identifier associated with an application that last accessed the data elements. In certain embodiments, removing the data elements from the cache comprises only removing the data elements from the cache if the application identifier matches one or more of the first application identifier and the second application identifier. A corresponding system and computer program product are also disclosed.