Various embodiments disclosed herein provide for a codeblock segmentation configuration system. A base station can configure the segmentation rate or segment size, which can control the number of codeblock segments a transport block is segmented into, based on the transmission reliability and predicted interference to a mobile device. An increased number of segments can improve throughput and efficiency when interference is low and signal to noise ratios are high, but can increase latency when interference is high and signal to noise is low. The base station can determine or predict transmission reliability based on the speed of mobile devices, the location and/or distance to the mobile device, as well as the long term signal to noise ratios.