Systems and methods for an end-to-end secure operation from an expression in natural language. Exemplary methods include: receiving a set of queries from a natural language processor, the set of queries being produced by a method including: getting data schemas associated with a target data source; obtaining the expression in natural language; performing natural language processing on the expression to determine a desired operation; and generating the set of queries using at least one of matching and inference techniques over the desired operation with respect to the data schemas; encrypting the set of queries using a homomorphic encryption technique; providing the encrypted set of queries to a server, the server including the target data source; acquiring encrypted results, the encrypted results being responsive to the encrypted set of queries; and decrypting the encrypted results using a decryption key to produce desired results.