A base station distributed unit may determine that a first uplink timing advance value for a first cell of a wireless device is different than a second uplink timing advance value for a second cell of the wireless device. The first cell and the second cell may belong to a first timing advance group. The base station distributed unit may transmit a first message to a base station central unit in response to the determining. The first message may comprise one or more information elements indicating a reconfiguration of a timing advance group configuration for the wireless device. The base station distributed unit may receive a radio resource control message from the base station central unit based on the reconfiguration for the wireless device.