Systems and methods are disclosed for transmission and reception of an uplink grant during a gap created in radio resources assigned by a previous multiple Transmit Time Interval (multi-TTI) uplink grant in a system operating according to a Time Division Duplexing (TDD) scheme. In one embodiment, a method of operation of a wireless device operating according to a TDD scheme in a cellular communications network includes: receiving a first uplink grant from a radio network node that assigns first radio resources for a first multiple transmit time interval uplink transmission, the first radio resources comprising a set of consecutive subframes; and interrupting an uplink transmission on the first radio resources during a gap in the first radio resources assigned for the first multiple transmit time interval uplink transmission, the gap comprising a time domain gap within the set of consecutive subframes.