In some examples, a method includes receiving a test image from a user or client, the test image depicting an anatomical region or structure of a human body, obtaining a reference image corresponding to the anatomical region or structure depicted in the test image, and analyzing the test image and the reference image to obtain a set of differences between the two images. In some examples, the method further includes, based at least in part on the set of differences, detecting a possible abnormality in the test image and outputting a result to the user or client. In some examples, a fast R-CNN is used to detecting the possible abnormality in the test image.