Embodiments included herein may be configured for managing one or more maximum transmission units (MTUs) for clustered and federated storage systems. Embodiments may include providing one or more heterogeneous storage clusters. A logical MTU may be configured on one or more leaf network interfaces of one or more networks. A physical network MTU may be configured on one or more intermediate network objects of the one or more networks. One or more physical network fabrics of the one or more networks may be managed. The physical network MTU may be managed via one of the one or more MTU domains. The physical network MTU may be reconfigured in response to determining the physical network MTU is outside of a pre-determined range.