Systems and methods are provided to implement moving target defense techniques for transportation systems. The moving target defense techniques can randomly change the IP addresses of the nodes associated with both the vehicles and the corresponding control centers. The nodes for the vehicles and the control centers can be “mobile” nodes that use a “care-of” IP address for communications. The care-of address used by the nodes can be updated through a binding update process. During the binding update process, the one node sends the binding update notice (with a new care-of address) to the care-of address of the other node while maintaining its prior care-of address. The node that receives the binding update notice can send a binding acknowledgement back to the node that sent the binding update. Once the binding acknowledgement is received, the prior care-of address can be removed by the node that sent the binding update.