A method includes generating spectral image data reproducible as one or more spectral images of a plurality of regions of interest in a sample. The method also includes analyzing the spectral image data to identify a plurality of scattering components in the spectral image data, each of the plurality of scattering components being associated with one or more biological properties of the sample. The method also includes identifying a feature of interest in the sample based at least in part on one or more the identified plurality of scattering components.