A brace for treating or preventing carpal tunnel injury includes a body having a proximal end and a distal end. The body includes a forearm support at the proximal end and a wrist support coupled to the forearm support by a neck portion. The wrist support includes a first palmar strap support. A first member and a second member extend from the wrist support towards the distal end. The body also includes a distal palmar support, a proximal palmar aperture, a palm band having a second palmar strap support, and a palmar strap. The palmar strap extends across a portion of the back of the hand and over a purlicue of the hand.