Invention Grant
- Patent Title: Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
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Application No.: US16620832Application Date: 2018-06-18
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Publication No.: US11213526B2Publication Date: 2022-01-04
- Inventor: Andreas G. Moraitis
- Applicant: Corcept Therapeutics, Inc.
- Applicant Address: US CA Menlo Park
- Assignee: Corcept Therapeutics, Inc.
- Current Assignee: Corcept Therapeutics, Inc.
- Current Assignee Address: US CA Menlo Park
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2018/038075 WO 20180618
- International Announcement: WO2018/236749 WO 20181227
- Main IPC: A61K31/4745
- IPC: A61K31/4745 ; A61K31/513 ; A61P35/00 ; A61K31/437

Abstract:
Applicant discloses methods for treating a glucocorticoid receptor positive (GR+) neuroepithelial tumor in a subject, comprising administering a selective glucocorticoid receptor modulator (SGRM) in an amount effective to reduce the tumor load in a subject. The GR+ neuroepithelial tumor may be a neurofibromatosis type 2 (NF 2) tumor; the GR+ neuroepithelial tumor may be a schwannoma, meningioma, or ependymoma. In embodiments, the GR+ neuroepithelial tumor is not an adrenocorticotropic hormone (ACTH)-secreting tumor. In embodiments, the SGRM comprises a steroidal backbone. In embodiments, the SGRM is mifepristone. In embodiments, the SGRM comprises a non-steroidal backbone, such as, e.g., a cyclohexyl pyrimidine, a fused azadecalin, a heteroaryl ketone fused azadecalin, or an octahydro fused azadecalin backbone. The SGRM may be administered orally. The SGRM may be administered alone. In embodiments, the SGRM is administered with at least one non-SGRM therapy, e.g., a chemotherapy, a radiation therapy, or other therapeutic agents.
Public/Granted literature
- US20200147082A1 METHODS OF TREATING NEUROEPITHELIAL TUMORS USING SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS Public/Granted day:2020-05-14
Information query
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