Invention Grant
- Patent Title: Poly(histidine)-based micelles for complexation and delivery of proteins and nucleic acids
-
Application No.: US16097187Application Date: 2017-04-28
-
Publication No.: US11213594B2Publication Date: 2022-01-04
- Inventor: Paiman Peter Ghoroghchian , Gabriela Romero Uribe , Eric Ostertag
- Applicant: Poseida Therapeutics, Inc.
- Applicant Address: US CA San Diego
- Assignee: Poseida Therapeutics, Inc.
- Current Assignee: Poseida Therapeutics, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Cooley LLP
- Agent Ivor Elrifi; Matthew Pavao
- International Application: PCT/US2017/030271 WO 20170428
- International Announcement: WO2017/190091 WO 20171102
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K47/69 ; A61K9/107 ; A61K31/7105 ; A61K31/711 ; A61K47/34 ; C12N15/90 ; A61K47/50 ; C12N15/88 ; C12N15/86 ; A61K38/00

Abstract:
Disclosed are compositions for delivering gene editing molecules to a cell. Exemplary compositions comprise a micelle assembled from a plurality of triblock copolymers, wherein each triblock copolymer having at least one hydrophobic block, at least one hydrophilic block, and at least one poly(L-histidine) block, wherein: the at least one poly(L-histidine) block complexes with the at least one gene editing molecule; and the at least one poly(L-histidine) block is capable of a pH dependent release of the at least one gene editing molecule.
Public/Granted literature
- US20190255191A1 POLY(HISTIDINE)-BASED MICELLES FOR COMPLEXATION AND DELIVERY OF PROTEINS AND NUCLEIC ACIDS Public/Granted day:2019-08-22
Information query