Invention Grant
![One pot synthesis of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid, a key intermediate of zilpaterol](/docs/US/2022-01-04/US11214551B2/abs.jpg.600x600.jpg)
- Patent Title: One pot synthesis of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid, a key intermediate of zilpaterol
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Application No.: US17050867Application Date: 2019-03-04
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Publication No.: US11214551B2Publication Date: 2022-01-04
- Inventor: Kannasani Ravi Kumar , Kasa Mallik Yadav , Mulu Sreenu , V. V. V Babu
- Applicant: RA CHEM PHARMA LIMITED
- Applicant Address: IN Hyderabad
- Assignee: RA CHEM PHARMA LIMITED
- Current Assignee: RA CHEM PHARMA LIMITED
- Current Assignee Address: IN Hyderabad
- Agency: Simpson & Simpson, PLLC
- Agent Michael Nicholas Vranjes
- Priority: IN201841016014 20180427
- International Application: PCT/IN2019/050186 WO 20190304
- International Announcement: WO2019/207591 WO 20191031
- Main IPC: C07D235/26
- IPC: C07D235/26
![One pot synthesis of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid, a key intermediate of zilpaterol](/abs-image/US/2022/01/04/US11214551B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to one pot process for the preparation of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid of Formula-I, which is a key intermediate and its use in the preparation of Zilpaterol, which comprises condensation of methyl-4-chloro butyrate with 1-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one in presence of a base and suitable solvent to give corresponding ester derivative, further hydrolyzation and acidification in presence of inorganic solvent to obtain Formula-I.
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