Invention Grant
- Patent Title: Gem-disubstituted pyrrolidines, piperazines, and diazepanes, and compositions and methods of making the same
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Application No.: US16657672Application Date: 2019-10-18
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Publication No.: US11214568B2Publication Date: 2022-01-04
- Inventor: Brian M. Stoltz , Alexander W. Sun , Stephan N. Hess , Carina I. Jette , Irina Geibel , Shoshana Bachman , Masaki Hayashi , Hideki Shimizu , Jeremy B. Morgan , Shunya Sakurai , Zachary P. Sercel
- Applicant: California Institute of Technology
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Foley Hoag LLP
- Agent Janine S. Ladislaw
- Main IPC: C07D243/08
- IPC: C07D243/08 ; C07D413/14 ; C07D207/26 ; C07D239/06 ; C07D507/00 ; C07D241/08
Abstract:
Described here are transition metal-catalyzed enantioselective arylation and vinylation reactions of α-substituted lactams, such as γ-lactams. The use of various electrophiles and ligands are described, and result in the construction of α-quaternary centers in good yields (up to 91% yield) and high enantioselectivities (up to 97% ee).
Information query
