Invention Grant
- Patent Title: PINK1 C-terminal domain polypeptide and methods using the same in cancer treatment
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Application No.: US15571249Application Date: 2016-05-02
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Publication No.: US11214774B2Publication Date: 2022-01-04
- Inventor: Pan-Chyr Yang , Pei-Ying Lin , Bo-Tsang Huang
- Applicant: Andrew Man Chung Wo , National Taiwan University , Academia Sinica
- Applicant Address: US MA Edgartown; TW Taipei; TW Taipei
- Assignee: Andrew Man Chung Wo,National Taiwan University,Academia Sinica
- Current Assignee: Andrew Man Chung Wo,National Taiwan University,Academia Sinica
- Current Assignee Address: US MA Edgartown; TW Taipei; TW Taipei
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Peter F. Corless; Joohee Lee
- International Application: PCT/US2016/030436 WO 20160502
- International Announcement: WO2016/179103 WO 20161110
- Main IPC: C07K5/00
- IPC: C07K5/00 ; C12N9/12 ; A61K45/06 ; C07K14/00 ; A61K39/395 ; C07K14/71 ; A61K31/517 ; A61K38/17 ; A61K31/5377 ; A61P35/00 ; A61K38/45
Abstract:
The present disclosure includes a PINK1-C-terminal domain (PINK1-CTD) polypeptide that binds to ERBB tyrosine kinase domain (ERBB-TKD) and therefore impedes ERBB from dimerization and activation. The PINK1-CTD polypeptide inhibits, prevents and/or treats ERBB-expressing cancers. The disclosure demonstrates the anti-tumor function of the PINK1-CTD, which provides a new direction for ERBB-expressing cancer therapy.
Public/Granted literature
- US20180112192A1 PINK1 C-TERMINAL DOMAIN POLYPEPTIDE AND METHODS USING THE SAME IN CANCER TREATMENT Public/Granted day:2018-04-26
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