Invention Grant
- Patent Title: Aptamers for the treatment of sickle cell disease
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Application No.: US16716570Application Date: 2019-12-17
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Publication No.: US11214804B2Publication Date: 2022-01-04
- Inventor: James F. Casella , Emily Barron-Casella , Jeffrey R. Keefer , Yolanda Fortenberry , Shirley H. Purvis
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Casimir Jones, S.C.
- Agent Lisa L. Mueller
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/115 ; G01N33/53 ; G01N33/72 ; C07K14/805
Abstract:
The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (HbS), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.
Public/Granted literature
- US20200332295A1 APTAMERS FOR THE TREATMENT OF SICKLE CELL DISEASE Public/Granted day:2020-10-22
Information query
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