Disclosed is a drying-wetting separated filling method and a filling apparatus for an electrowetting display device. The filling method comprises filling a non-polar solution into pixel grids on a lower substrate of an electrowetting display device in air, and filling a polar solution to immediately cover the non-polar solution filled after filling the non-polar solution into the pixel grids. Compared with filling the non-polar solution into the polar solution, directly filling the non-polar solution in air has better filling uniformity, easier operation and control. With the method, the fillings of the polar solution and the non-polar solution are easy, having a higher filling efficiency, and no air bubble residue.