A video blind denoising method based on deep learning, a computer device and a computer-readable storage medium. The method includes: taking a video sequence from a video to be denoised, taking the middle frame in the video sequence as a noisy reference frame, performing an optical flow estimation on the image corresponding to the noisy reference frame and each other frame in the video sequence, to obtain optical flow fields; transforming, according to the optical flow fields, the image corresponding to each other frame in the video sequence to the noisy reference frame for registration respectively, to obtain multi-frame noisy registration images; taking the multi-frame noisy registration images as an input of a convolutional neural network, taking the noisy reference frame as the reference image, performing iterative training and denoising by using the noise2noise training principle, to obtain the denoised image. This solution may achieve the blind denoising of a video.