Methods, apparatus, systems and articles of manufacture are disclosed to adjust audio playback settings based on analysis of audio characteristics. Example apparatus disclosed herein include an equalization (EQ) model query generator to generate a query to a neural network, the query including a representation of a sample of an audio signal; an EQ filter settings analyzer to: access a plurality of audio playback settings determined by the neural network based on the query; and determine a filter coefficient to apply to the audio signal based on the plurality of audio playback settings; and an EQ adjustment implementer to apply the filter coefficient to the audio signal in a first duration.