A hybrid data processing environment, including a classical and a quantum computing system, is configured. A configuration of a first quantum circuit, executable using the quantum computing system is produced. A first analysis operation is configured for use in a first analysis pass. The first analysis operation specifies a type of analysis to be performed on the quantum circuit. Using an output of an execution of the first analysis operation, a portion of the first quantum circuit that should be transformed to satisfy a constraint on the quantum circuit design is identified. In a first transformation pass according to a first transformation operation, the portion is transformed, resulting in a second quantum circuit, by reconfiguring a gate in the first quantum circuit such that a qubit used in the gate complies with the constraint on the quantum circuit design while participating in the second quantum circuit.