Disclosed herein are systems and method for de-duplicating blocks of data. In one aspect, an exemplary method comprises for each previously de-duplicated block of data of a de-duplication engine, storing de-duplicated pages references by hashes and a block descriptor. The method comprises receiving, at the de-duplication engine, a new block of data for de-duplication assessment and determining a similarity of the received block to the previously de-duplicated blocks. When the received block is determined as being similar to the previously de-duplicated blocks, the method comprises storing the received block without duplication in the de-duplication engine, including pages of the block referenced by the hashes and the block descriptor.