A method for hot plug memory device data protection is provided. Removal of a hot plug memory device from a connection interface is determined by a status of an interface plug-in detection signal, wherein the hot plug memory device is electrically coupled to a host through the connection interface. A command for moving data is transmitted to the hot plug memory device by the host. Temporary data is moved from a cache module of the hot plug memory device to a flash memory module of the hot plug memory device by the hot plug memory device in response to the command for moving data.