This disclosure details exemplary electrical architectural layouts for distributing high voltage power within electrified vehicles. An exemplary battery pack associated with an electrical architectural layout of an electrified vehicle may include an enclosure assembly that houses one or more battery arrays. The battery arrays may be efficiently arranged relative to one another inside the enclosure assembly to establish an open channel within the enclosure assembly. A high voltage wiring harness may be routed through an interior of the battery pack within the open channel. The exemplary electrical architectural layouts of this disclosure may be employed within all-wheel drive, rear-wheel drive, or front-wheel drive electrified vehicles.