A waveguide feed substrate and a manufacturing method thereof, and an antenna system and a manufacturing method thereof are provided. The waveguide feed substrate comprises: a first base substrate provided with a receiving groove; and a waveguide feeder embedded in the receiving groove and provided with a first side disposed at a bottom of the receiving groove, a second side disposed opposite to the first side, a third side disposed on a first side wall of the receiving cell, and a fourth side disposed on a second side wall of the receiving cell; wherein an opening is disposed in the second side, and an upper surface of the second side is flush with an upper surface of the first base substrate.