A method of ablating tissue comprising adjusting a set of dosing parameters for an ablation catheter based on a set of optical image-derived parameters generated from optical image-derived information obtained from direct optical imaging of the tissue while the ablation catheter is in contact with the tissue. The set of optical image-derived parameters may include a color profile, a blanching parameter, or a contact angle of a distal tip of the ablation catheter. The method may further comprise comparing the color profile to a signature profile and adjusting the set of dosing parameters based on the comparison between the color profile and the signature profile.