Invention Grant
- Patent Title: Methods and compositions for heterologous repRNA immunizations
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Application No.: US16634205Application Date: 2018-07-27
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Publication No.: US11235051B2Publication Date: 2022-02-01
- Inventor: Ronald Vogels , Marijn Van Der Neut Kolfschoten , Darrell J. Irvine , Ron Weiss , Ely Blanton Porter , Mariane Bandeira Melo , Tasuku Kitada
- Applicant: Janssen Vaccines & Prevention B.V. , Massachusetts Institute of Technology
- Applicant Address: NL Leiden; US MA Cambridge
- Assignee: Janssen Vaccines & Prevention B.V.,Massachusetts Institute of Technology
- Current Assignee: Janssen Vaccines & Prevention B.V.,Massachusetts Institute of Technology
- Current Assignee Address: NL Leiden; US MA Cambridge
- Agency: Ice Miller LLP
- International Application: PCT/US2018/044075 WO 20180727
- International Announcement: WO2019/023566 WO 20190131
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K9/127 ; C07K14/535 ; C12N15/85 ; A61K31/7115 ; A61K39/12 ; C12N15/86 ; A61K39/00
Abstract:
Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.
Public/Granted literature
- US20200230225A1 METHODS AND COMPOSITIONS FOR HETEROLOGOUS REPRNA IMMUNIZATIONS Public/Granted day:2020-07-23
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