Invention Grant
- Patent Title: Peptide hydrogels generating chemical exchange saturation transfer MRI contrast and uses thereof
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Application No.: US14787039Application Date: 2014-04-28
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Publication No.: US11235075B2Publication Date: 2022-02-01
- Inventor: Michael T. McMahon , Kannie Wai-Yan Chan , Michael Christopher Giano , Nikita Oskolkov , Joel Patrick Schneider , Xiaolei Song
- Applicant: THE JOHNS HOPKINS UNIVERSITY , KENNEDY KRIEGER INSTITUTE, INC. , NATIONAL INSTITUTES OF HEALTH
- Applicant Address: US MD Baltimore; US MD Baltimore; US MD Bethesda
- Assignee: THE JOHNS HOPKINS UNIVERSITY,KENNEDY KRIEGER INSTITUTE, INC.,NATIONAL INSTITUTES OF HEALTH
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY,KENNEDY KRIEGER INSTITUTE, INC.,NATIONAL INSTITUTES OF HEALTH
- Current Assignee Address: US MD Baltimore; US MD Baltimore; US MD Bethesda
- Agency: Casimir Jones, S.C.
- Agent Kelly A. Barton
- International Application: PCT/US2014/035651 WO 20140428
- International Announcement: WO2014/176586 WO 20141030
- Main IPC: A61B5/055
- IPC: A61B5/055 ; A61K49/18 ; A61K49/14
Abstract:
The present invention provides novel hydrogels through peptides, which are designed to self-assemble and produce magnetic resonance (MR) contrast through chemical exchange saturation transfer (CEST). The location and integrity of these gels could consequently be tracked using MR imaging. The self-assembly of the peptides into hydrogels can be brought about by a change in pH, ionic strength, temperature, and concentration of ions.
Public/Granted literature
- US20160106871A1 NOVEL PEPTIDE HYDROGELS GENERATING CHEMICAL EXCHANGE SATURATION TRANSFER MRI CONTRAST AND USES THEREOF Public/Granted day:2016-04-21
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