A filter cartridge with easier extraction provided by a roll-out clearance region for a radial seal is provided. The filter cartridge may be a two stage filter with the seal being located between stages and usable in a filtration vessel having a central separation wall with one or more riser pipes. Also, a new vessel is disclosed with multiple diameters for first and second stages of the housing with a larger second stage diameter as compared to the first stage, which can reduce door size and/or cause fluid flow velocities to be slower at the second stage relative to the first stage.