The present disclosure provides a method, an apparatus, a device and a readable storage medium for preventing a vehicle collision. The method includes determining a current conservative anti-collision region of a vehicle acquiring the omnidirectional environmental information in the current region in the current conservative anti-collision region; predicting a behavior of an obstacle according to the omnidirectional environmental information in the current region, and controlling the vehicle to conduct an anti-collision behavior according a prediction result, a reasonable prediction may be made to the behavior of the obstacle based on the conservative anti-collision region and the omnidirectional environmental information, thus controlling the vehicle to conduct an accurate anti-collision behavior, thereby preventing collisions effectively, and avoiding an occurrence of traffic accidents.