Invention Grant
- Patent Title: Selective inhibitors of 12(S)-lipoxygenase (12-LOX) and methods for use of the same
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Application No.: US17047427Application Date: 2019-04-17
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Publication No.: US11236044B2Publication Date: 2022-02-01
- Inventor: Michael Holinstat , Reheman Adili , Andrew White
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: Marshall, Gerstein & Borun LLP
- International Application: PCT/US2019/027785 WO 20190417
- International Announcement: WO2019/204375 WO 20191024
- Main IPC: C07C311/44
- IPC: C07C311/44 ; C07D209/40 ; A61P7/02
Abstract:
Disclosed herein are small molecule inhibitors of 12(S)-Lipoxygenase (12-LOX), and methods of using the small molecules to inhibit 12-LOX activation and to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.
Public/Granted literature
- US20210147348A1 SELECTIVE INHIBITORS OF 12(S)- LIPOXYGENASE (12-LOX) AND METHODS FOR USE OF THE SAME Public/Granted day:2021-05-20
Information query
