Invention Grant
- Patent Title: Substituted azaindoline derivatives as NIK inhibitors
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Application No.: US16622016Application Date: 2018-07-04
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Publication No.: US11236084B2Publication Date: 2022-02-01
- Inventor: George Hynd , Calum Macleod , Samuel Edward Mann , Janusz Jozef Kulagowski , Ian Stansfield , Olivier Alexis Georges Querolle , Virginie Sophie Poncelet , Gerhard Max Gross , Edgar Jacoby , Lieven Meerpoel
- Applicant: Janssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP17180010 20170706
- International Application: PCT/EP2018/068048 WO 20180704
- International Announcement: WO2019/008011 WO 20190110
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D519/00

Abstract:
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
Public/Granted literature
- US20210188840A1 NEW SUBSTITUTED AZAINDOLINE DERIVATIVES AS NIK INHIBITORS Public/Granted day:2021-06-24
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