Invention Grant
- Patent Title: Solid state forms
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Application No.: US16878824Application Date: 2020-05-20
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Publication No.: US11236091B2Publication Date: 2022-02-01
- Inventor: Mary Chaves , Patricia Lopez , Prashant Agarwal , Albert Amegadzie , Stephanie Azali , Roman Shimanovich , Ron C. Kelly , Darren Leonard Reid
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Markus Bergauer
- Main IPC: C07D471/04
- IPC: C07D471/04

Abstract:
The present disclosure provides crystalline and amorphous forms of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1-piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several anhydrous, hydrate and solvate forms, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.
Public/Granted literature
- US20200369662A1 SOLID STATE FORMS Public/Granted day:2020-11-26
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