Invention Grant
- Patent Title: 11,13-modified saxitoxins for the treatment of pain
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Application No.: US16499205Application Date: 2018-03-29
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Publication No.: US11236097B2Publication Date: 2022-02-01
- Inventor: John Mulcahy , Hassan Pajouhesh , George Miljanich , Anton Delwig , Jacob Beckley , Grant Masaaki Shibuya , Justin Du Bois
- Applicant: SITEONE THERAPEUTICS, INC. , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Applicant Address: US MT Bozeman; US CA Stanford
- Assignee: SITEONE THERAPEUTICS, INC.,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee: SITEONE THERAPEUTICS, INC.,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
- Current Assignee Address: US MT Bozeman; US CA Stanford
- Agency: Squire Patton Boggs (US) LLP
- International Application: PCT/US2018/025301 WO 20180329
- International Announcement: WO2018/183781 WO 20181004
- Main IPC: C07D487/14
- IPC: C07D487/14
Abstract:
Provided herein are compounds, pharmaceutical compositions comprising the compounds, methods of preparing the compounds, and methods of using the compounds and compositions in treating conditions associated with voltage-gated sodium channel function where the compounds are 11,13-modified saxitoxins according to Formula (I): where R4, R4a, R7, R7a, and X2 are as described herein.
Information query
