Invention Grant
- Patent Title: Crystal of tricyclic compound
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Application No.: US16639395Application Date: 2018-08-17
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Publication No.: US11236107B2Publication Date: 2022-02-01
- Inventor: Shilan Liu , Dahai Wang , Guibai Liang , Honglin Wang , Guoping Hu , Jian Li , Shuhui Chen
- Applicant: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Applicant Address: CN Lianyungang
- Assignee: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Current Assignee: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
- Current Assignee Address: CN Lianyungang
- Agency: Nixon Peabody LLP
- Priority: CN201710714247.3 20170818
- International Application: PCT/CN2018/100988 WO 20180817
- International Announcement: WO2019/034139 WO 20190221
- Main IPC: C07D495/14
- IPC: C07D495/14 ; A61K31/4188 ; A61P37/00

Abstract:
The present application relates to a crystal of a tricyclic compound, in particular to a crystal of (S)-8-(4,4-difluorocyclohexyl)-8H-thieno[3,4]pyrrolo[1,5-a]imidazole, a preparation method therefor, a crystal composition and a pharmaceutical composition thereof and the use thereof. The X-ray powder diffraction spectrum of the crystal of the compound of formula I in the present application, represented by a 2θ value, has a diffraction peak at about 11.49°, 15.05°, 20.14°, 21.53° or 21.79°. The crystal of the compound of formula I in the present application has excellent physical properties, high safety and metabolic stability, and has a good inhibitory effect on IDO and a high medicinal value.
Public/Granted literature
- US20200255449A1 CRYSTAL OF TRICYCLIC COMPOUND Public/Granted day:2020-08-13
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