Invention Grant
- Patent Title: Method for preparation of peptides with psWang linker
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Application No.: US16071344Application Date: 2017-01-20
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Publication No.: US11236123B2Publication Date: 2022-02-01
- Inventor: Luciano Forni , Daniel Carbajo Lopez , Fernando Albericio Palomera
- Applicant: Polypeptide Laboratories Holding (PPL) AB
- Applicant Address: SE Limhamn
- Assignee: Polypeptide Laboratories Holding (PPL) AB
- Current Assignee: Polypeptide Laboratories Holding (PPL) AB
- Current Assignee Address: SE Limhamn
- Agency: Dority & Manning, P.A.
- Priority: EP16152145 20160120,EP16153974 20160202,EP16154977 20160202,EP16197210 20161104,EP16197345 20161104
- International Application: PCT/SE2017/000006 WO 20170120
- International Announcement: WO2017/127007 WO 20170727
- Main IPC: C40B50/08
- IPC: C40B50/08 ; C07K1/10 ; C07K1/02 ; C07K14/605

Abstract:
The invention discloses a method for the preparation of a peptide by liquid phase coupling of two fragments, an N-terminal fragment and a C-terminal fragment of the desired peptide, wherein the C-terminal fragment is protected on its C-terminal COOH by a psWang linker; the method is demonstrated with liraglutide wherein the C-terminal fragment carries the Palmitoyl-Glu-OtBu residue on the Lys.
Public/Granted literature
- US20200024306A1 Method for Preparation of Peptides with psWANG Linker Public/Granted day:2020-01-23
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