Invention Grant
- Patent Title: Methods for enhanced removal of impurities during protein A chromatography
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Application No.: US16228291Application Date: 2018-12-20
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Publication No.: US11236126B2Publication Date: 2022-02-01
- Inventor: Carl A. Beigie
- Applicant: Genzyme Corporation
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Morrison & Foerster LLP
- Main IPC: C07K1/22
- IPC: C07K1/22 ; C07K16/00 ; B01D15/38 ; B01D15/42 ; C07K1/34 ; C07K1/36
Abstract:
Provided herein are methods relating to the purification of a polypeptide comprising an Fc region (e.g., an antibody) via protein A chromatography; methods relating to the use of a wash solution comprising a benzoate salt and/or benzyl alcohol during protein A chromatography; and methods of adjusting a harvest using sodium benzoate prior to protein A chromatography.
Public/Granted literature
- US20190233468A1 METHODS FOR ENHANCED REMOVAL OF IMPURITIES DURING PROTEIN A CHROMATOGRAPHY Public/Granted day:2019-08-01
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