Invention Grant
- Patent Title: Nucleic acids encoding HIV-1 GP140 immunogens comprising modified NHR1 regions that stabilize pre-fusion conformations
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Application No.: US16780495Application Date: 2020-02-03
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Publication No.: US11236134B2Publication Date: 2022-02-01
- Inventor: Leopold Kong , Ian A. Wilson , Natalia De Val , Andrew B. Ward , Dennis Burton , Linling He , Jiang Zhu
- Applicant: The Scripps Research Institute
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agent Hugh Wang; Thomas Fitting
- Main IPC: C07K14/16
- IPC: C07K14/16 ; A61K47/69 ; A61K39/21 ; C07K14/005 ; A61K39/12 ; A61K47/64 ; A61K39/00
Abstract:
The present invention provides HIV-1 vaccine immunogens. Some of the immunogens contain a soluble gp140-derived protein that harbors a modified N-terminus of the HR1 region in gp41. Some of the immunogens contain an HIV-1 Env-derived trimer protein that is presented on a nanoparticle platform. The invention also provides methods of using the HIV-1 vaccine immunogens for eliciting an immune response or treating HIV infections.
Public/Granted literature
- US20200165303A1 Compositions and Methods Related to HIV-1 Immunogens Public/Granted day:2020-05-28
Information query
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