Invention Grant
- Patent Title: Stable pharmaceutical formulation
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Application No.: US16345453Application Date: 2017-10-26
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Publication No.: US11236146B2Publication Date: 2022-02-01
- Inventor: Joon Won Lee , Won Yong Han , Su Jung Kim , Jun Seok Oh , So Young Kim , Kwang Woo Kim , Yeon Kyeong Shin
- Applicant: CELLTRION INC.
- Applicant Address: KR Incheon
- Assignee: CELLTRION INC.
- Current Assignee: CELLTRION INC.
- Current Assignee Address: KR Incheon
- Agency: BakerHostetler
- Priority: KR10-2016-0142184 20161028
- International Application: PCT/KR2017/011909 WO 20171026
- International Announcement: WO2018/080196 WO 20180503
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K14/705 ; A61K9/08 ; A61K47/02 ; A61K47/18 ; A61K47/26 ; A61K47/12 ; A61K38/16 ; A61K38/19 ; A61K38/17

Abstract:
Disclosed is a stable pharmaceutical formulation, comprising a fusion protein in which the extracellular ligand-binding domain of a human p75 tumor necrosis factor receptor is fused to the Fc domain of human IgG and a succinate buffering agent, without comprising a stabilizer. The stable pharmaceutical formulation enables the long-term storage of the TNFR-Fc fusion protein formulation and can exhibit superior storage stability without the need for demanding storage conditions, and is a simple formulation because no stabilizer is comprised therein and is thus more economical than other stabilizer-comprising formulations.
Public/Granted literature
- US20190248871A1 STABLE PHARMACEUTICAL FORMULATION Public/Granted day:2019-08-15
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