Invention Grant
- Patent Title: Neutralizing antibodies to HIV-1 GP41 and their use
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Application No.: US15772443Application Date: 2016-11-03
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Publication No.: US11236152B2Publication Date: 2022-02-01
- Inventor: Peter Kwong , Young Do Kwon , Ivelin Georgiev , Gilad Ofek , Baoshan Zhang , Krisha McKee , John Mascola , Mark Connors , Gwo-Yu Chuang , Sijy O'Dell , Robert Bailer , Mark Louder , Mangaiarkarasi Asokan , Richard Schwartz , Jonathan Cooper , Kevin Carlton , Michael Bender , Amarendra Pegu , Lawrence Shapiro , Tatyana Gindin , Lisa Kueltzo
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services , The Trustees of Columbia University in the City of New York
- Applicant Address: US MD Bethesda; US NY New York
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,The Trustees of Columbia University in the City of New York
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services,The Trustees of Columbia University in the City of New York
- Current Assignee Address: US MD Bethesda; US NY New York
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2016/060390 WO 20161103
- International Announcement: WO2017/079479 WO 20170511
- Main IPC: C07K16/10
- IPC: C07K16/10 ; A61P31/18
Abstract:
Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
Public/Granted literature
- US20190077849A1 NEUTRALIZING ANTIBODIES TO HIV-1 GP41 AND THEIR USE Public/Granted day:2019-03-14
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