Invention Grant
- Patent Title: Compositions and methods for targeting activin signaling to treat cancer
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Application No.: US16077368Application Date: 2017-02-10
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Publication No.: US11236156B2Publication Date: 2022-02-01
- Inventor: Fan Pan , Duojia Pan , Drew M. Pardoll , Joseph Barbi , Juan Fu
- Applicant: The Johns Hopkins University
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Peter F. Corless; Nicholas A. Zachariades
- International Application: PCT/US2017/017354 WO 20170210
- International Announcement: WO2017/139564 WO 20170817
- Main IPC: C07K16/22
- IPC: C07K16/22 ; A61K39/395 ; A61P35/00 ; A61K39/00 ; A61P17/06 ; A61P19/02 ; A61K31/7105 ; A61K38/17
Abstract:
The present invention relates to compositions and methods for treating cancer by targeting the Activin signaling pathway. In certain embodiments, combining Activin blockade with immunomodulation alters regulatory T (Treg) cell-mediated immune regulation and treats cancer.
Public/Granted literature
- US20190077855A1 COMPOSITIONS AND METHODS FOR TARGETING ACTIVIN SIGNALING TO TREAT CANCER Public/Granted day:2019-03-14
Information query
