Invention Grant
- Patent Title: CD34+CD41DIM megakaryocytes progenitors and uses thereof for producing proplatelet-bearing MKs and/or platelets
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Application No.: US15747023Application Date: 2016-07-22
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Publication No.: US11236303B2Publication Date: 2022-02-01
- Inventor: Catherine Strassel , Christian Gachet , François Lanza , Nathalie Brouard
- Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Etablissement Français du Sang
- Applicant Address: FR Paris; FR La Plaine Saint Denis
- Assignee: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),Etablissement Français du Sang
- Current Assignee: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM),Etablissement Français du Sang
- Current Assignee Address: FR Paris; FR La Plaine Saint Denis
- Agency: Stites & Harbison, PLLC
- Agent B. Aaron Schulman, Esq.
- Priority: FR1557020 20150723
- International Application: PCT/EP2016/067594 WO 20160722
- International Announcement: WO2017/013262 WO 20170126
- Main IPC: C12N5/078
- IPC: C12N5/078
Abstract:
The invention relates to a method of producing CD34+CD4dim megakaryocyte (MK) progenitor cells, and substantially pure cell population of megakaryocyte precursor cells obtained by said method. The invention also relates to a method of producing proplatelet-bearing MKs and/or platelets using the CD34+CD4dim cells.
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