Invention Grant
- Patent Title: Process to prepare elongated 2-ketoacids and C-5-C10 compounds therefrom via genetic modifications to microbial metabolic pathways
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Application No.: US16337072Application Date: 2016-12-30
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Publication No.: US11236310B2Publication Date: 2022-02-01
- Inventor: Paresh C. Sanghani , Eric C. Shiue , Scott A. Greenwalt , Prakash Bhosale , Sarah Delaplane , Christopher C. Stowers
- Applicant: Dow Global Technologies LLC
- Applicant Address: US MI Midland
- Assignee: Dow Global Technologies LLC
- Current Assignee: Dow Global Technologies LLC
- Current Assignee Address: US MI Midland
- Agency: Dinsmore & Shohl LLP
- International Application: PCT/US2016/069476 WO 20161230
- International Announcement: WO2018/063424 WO 20180405
- Main IPC: C12N9/88
- IPC: C12N9/88 ; C12P7/04 ; C12N9/10 ; C12P7/24 ; C12P7/40 ; C12N9/04 ; C12P7/44 ; C12N15/52 ; C12N9/02 ; C12P5/02
Abstract:
Genetically modified LeuCD′ enzyme complexes, processes for preparing a C7-C11 2-ketoacid utilizing genetically modified LeuCD′ enzyme complexes, and microbial organisms including modified LeuCD enzyme complexes are described. The instantly-disclosed genetically modified LeuCD′ enzyme complexes, processes for preparing a C7-C11 2-ketoacid, and microbial organisms including modified LeuCD′ enzyme complexes can be particularly useful for producing C6-C10 aldehydes, alkanes, alcohols, and carboxylic acids, both in vivo and in vitro.
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