Invention Grant
- Patent Title: MicroRNAs for cardiac regeneration through induction of cardiac myocyte proliferation
-
Application No.: US16400333Application Date: 2019-05-01
-
Publication No.: US11236332B2Publication Date: 2022-02-01
- Inventor: Mauro Giacca , Serena Zacchigna , Miguel Luis Cunha Mano , Ana Sofia Bregieiro Eulalio
- Applicant: INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY-ICGEB
- Applicant Address: IT Trieste
- Assignee: INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY-ICGEB
- Current Assignee: INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY-ICGEB
- Current Assignee Address: IT Trieste
- Agency: Nxon & Vanderhye, PC
- Priority: ITRM2011A000685 20111223
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113 ; C12N5/077 ; G01N33/50 ; A61K48/00
Abstract:
The present invention discloses a set of human microRNAs, or a primary transcript for such microRNAs, or a precursor of such microRNAs, or a mimic of such microRNAs or a combination thereof, and their use as medicaments for inducing proliferation of cardiomyocytes for the prevention and treatment of heart diseases associated with a loss of cardiomyocytes. The invention also relates to a method for screening microRNAs and biological and therapeutically active compounds for their ability to increase proliferation of cardiomyocytes.
Public/Granted literature
- US20190256850A1 MICRORNAS FOR CARDIAC REGENERATION THROUGH INDUCTION OF CARDIAC MYOCYTE PROLIFERATION Public/Granted day:2019-08-22
Information query
IPC分类:
