Invention Grant
- Patent Title: Method of reducing the effects of aging-associated impairment of neurogenesis comprising modulating c-c chemokine receptor type 3 (CCR3)
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Application No.: US16842054Application Date: 2020-04-07
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Publication No.: US11236340B2Publication Date: 2022-02-01
- Inventor: Anton Wyss-Coray , Thomas A. Rando , Markus Britschgi , Kaspar Rufibach , Saul A. Villeda
- Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
- Applicant Address: US CA Stanford; US DC Washington
- Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY,THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
- Current Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY,THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
- Current Assignee Address: US CA Stanford; US DC Washington
- Agency: Casimir Jones, S.C.
- Agent Tanya A. Arenson
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07K16/24 ; A61K31/00 ; A61K31/7088 ; C07K16/28 ; A61K39/00 ; A61K38/19 ; A61K38/45 ; C12Q1/6883
Abstract:
Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating eotaxin-1/CCR3 interaction, in the mammal in a manner sufficient to treat the mammal for the aging-associated impairment. A variety of aging-associated impairments may be treated by practice of the methods, which impairments include cognitive impairments.
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